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Synthesis 2016; 48(04): 595-605
DOI: 10.1055/s-0035-1560966
DOI: 10.1055/s-0035-1560966
paper
Diversity-Oriented Synthesis of Spiropyrazolone-Based Tetrahydropyrroles via Three-Component 1,3-Dipolar Cycloadditions
Autoren
Weitere Informationen
Publikationsverlauf
Received: 23. September 2015
Accepted after revision: 27. Oktober 2015
Publikationsdatum:
25. November 2015 (online)
Abstract
A highly efficient method for the synthesis of spiropyrazolone derivatives with structural diversity has been established via a facile three-component 1,3-dipolar cycloaddition of aldehydes, amino ester, and unsaturated pyrazolones. This protocol is applicable to a variety of unsaturated pyrazolones and aldehyde-derived azomethine ylides, providing an easy access to spiropyrazolone-based tetrahydropyrroles with structural diversity in high yields (up to 97%).
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560966.
- Supporting Information (PDF) (opens in new window)
-
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For some reviews, see:
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