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Synthesis 2015; 47(23): 3711-3716
DOI: 10.1055/s-0035-1560070
DOI: 10.1055/s-0035-1560070
paper
A First Synthesis of Bis(benzoxazole) Natural Products: Nataxazole and AJI9561 via Benzoxazole C–H Activation
Authors
Further Information
Publication History
Received: 25 May 2015
Accepted after revision: 07 July 2015
Publication Date:
18 August 2015 (online)
Abstract
Concise and efficient syntheses of nataxazole and AJI9561 have been accomplished. We also demonstrate a convenient route to obtain the related natural product UK-1. The key step involves C–H activation of a benzoxazole in the presence of ortho-iodoanilides using a copper(I) iodide/Xantphos/palladium(II) acetate system.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560070.
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