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Am J Perinatol 2015; 32(05): 417-426
DOI: 10.1055/s-0034-1395476
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Use of Antenatal Corticosteroids in the Management of Preterm Delivery

Anthony K. Msan
1   Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
,
Ihab M. Usta
1   Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
,
Fadi G. Mirza
1   Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
,
Anwar H. Nassar
1   Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
› Author Affiliations
Further Information

Publication History

12 May 2014

23 September 2014

Publication Date:
23 December 2014 (online)

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Abstract

Objective This narrative review of the literature explores the current evidence and recommendations in favor of antenatal corticosteroids use during impending preterm deliveries as well as related issues and concerns.

Study Design Synthesis of findings from published medical literature on antenatal corticosteroids and prematurity, retrieved from searches of computerized databases and authoritative texts.

Results It is now recognized that an intramuscular course of betamethasone or dexamethasone given to a woman expected to deliver preterm not only accelerates pulmonary epithelial development but also matures other organ systems, significantly decreasing the chances of neonatal morbidities and increasing chances of survival.

Conclusion There remain uncertainties over the efficacy of the established protocol in populations such as the very early preterm, the late preterm, and multiple gestations. Alternative regimens remain controversial because of fear of adverse effects and doubts regarding whether benefits outweigh risks.

Keywords

antenatal corticosteroids - prematurity - betamethasone - dexamethasone
 

  • References

  • 1 Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008; 371 (9608) 261-269
    CrossrefPubMedGoogle Scholar
  • 2 Matthews TJ, MacDorman MF. Infant mortality statistics from the 2010 period linked birth/infant death data set. Natl Vital Stat Rep 2013; 62 (8) 1-26
    PubMedGoogle Scholar
  • 3 Blencowe H, Cousens S, Oestergaard MZ , et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 2012; 379 (9832) 2162-2172
    CrossrefPubMedGoogle Scholar
  • 4 Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med 2010; 362 (6) 529-535
    Google Scholar
  • 5 Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006; (3) CD004454
    PubMedGoogle Scholar
  • 6 Hamvas A. Pathophysiology and management of respiratory distress syndrome. In: Martin RJ, Fanaroff AA, Walsh MC, , eds. Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 9th ed. Philadelphia: Mosby/Elsevier; 2011: 1106-1116
    Google Scholar
  • 7 Ballard PL, Ballard RA. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. Am J Obstet Gynecol 1995; 173 (1) 254-262
    CrossrefPubMedGoogle Scholar
  • 8 Ballard PL. Scientific rationale for the use of antenatal glucocorticoids to promote fetal development. Pediatr Rev 2000; 1 (5) E83-E90
    PubMedGoogle Scholar
  • 9 Schmid W, Cole TJ, Blendy JA, Schütz G. Molecular genetic analysis of glucocorticoid signalling in development. J Steroid Biochem Mol Biol 1995; 53 (1-6) 33-35
    CrossrefPubMedGoogle Scholar
  • 10 Bolt RJ, van Weissenbruch MM, Lafeber HN, Delemarre-van de Waal HA. Glucocorticoids and lung development in the fetus and preterm infant. Pediatr Pulmonol 2001; 32 (1) 76-91
    CrossrefPubMedGoogle Scholar
  • 11 Rooney SA, Young SL, Mendelson CR. Molecular and cellular processing of lung surfactant. FASEB J 1994; 8 (12) 957-967
    PubMedGoogle Scholar
  • 12 Wilms FF, Vis JY, Pattinaja DA , et al. Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity. Am J Obstet Gynecol 2011; 205 (1) e1-e7
    CrossrefPubMedGoogle Scholar
  • 13 Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972; 50 (4) 515-525
    PubMedGoogle Scholar
  • 14 Brownfoot FC, Gagliardi DI, Bain E, Middleton P, Crowther CA. Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2013; 8: CD006764
    Google Scholar
  • 15 Moore LE, Martin Jr JN. When betamethasone and dexamethasone are unavailable: hydrocortisone. J Perinatol 2001; 21 (7) 456-458
    CrossrefPubMedGoogle Scholar
  • 16 Morrison JC, Whybrew WD, Bucovaz ET, Schneider JM. Injection of corticosteroids into mother to prevent neonatal respiratory distress syndrome. Am J Obstet Gynecol 1978; 131 (4) 358-366
    PubMedGoogle Scholar
  • 17 Morrison JL, Botting KJ, Soo PS , et al. Antenatal steroids and the IUGR fetus: are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses?. J Pregnancy 2012; 2012: 839656
    PubMedGoogle Scholar
  • 18 Lee BH, Stoll BJ, McDonald SA, Higgins RD ; National Institute of Child Health and Human Development Neonatal Research Network. Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics 2006; 117 (5) 1503-1510
    CrossrefPubMedGoogle Scholar
  • 19 Lee BH, Stoll BJ, McDonald SA, Higgins RD ; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone. Pediatrics 2008; 121 (2) 289-296
    CrossrefPubMedGoogle Scholar
  • 20 Feldman DM, Carbone J, Belden L, Borgida AF, Herson V. Betamethasone vs dexamethasone for the prevention of morbidity in very-low-birthweight neonates. Am J Obstet Gynecol 2007; 197 (3) e1-e4
    PubMedGoogle Scholar
  • 21 Baud O, Foix-L'Helias L, Kaminski M , et al. Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants. N Engl J Med 1999; 341 (16) 1190-1196
    CrossrefPubMedGoogle Scholar
  • 22 Pattanittum P, Ewens MR, Laopaiboon M, Lumbiganon P, McDonald SJ, Crowther CA ; SEA-ORCHID Study Group. Use of antenatal corticosteroids prior to preterm birth in four South East Asian countries within the SEA-ORCHID project. BMC Pregnancy Childbirth 2008; 8: 47
    CrossrefPubMedGoogle Scholar
  • 23 Rotmensch S, Liberati M, Vishne TH, Celentano C, Ben-Rafael Z, Bellati U. The effect of betamethasone and dexamethasone on fetal heart rate patterns and biophysical activities. A prospective randomized trial. Acta Obstet Gynecol Scand 1999; 78 (6) 493-500
    CrossrefPubMedGoogle Scholar
  • 24 Mushkat Y, Ascher-Landsberg J, Keidar R, Carmon E, Pauzner D, David MP. The effect of betamethasone versus dexamethasone on fetal biophysical parameters. Eur J Obstet Gynecol Reprod Biol 2001; 97 (1) 50-52
    CrossrefPubMedGoogle Scholar
  • 25 Buttgereit F, Brand MD, Burmester GR. Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy. Biochem Pharmacol 1999; 58 (2) 363-368
    CrossrefPubMedGoogle Scholar
  • 26 Crowther CA, Harding JE, Middleton PF, Andersen CC, Ashwood P, Robinson JS ; A*STEROID Study Group. Australasian randomised trial to evaluate the role of maternal intramuscular dexamethasone versus betamethasone prior to preterm birth to increase survival free of childhood neurosensory disability (A*STEROID): study protocol. BMC Pregnancy Childbirth 2013; 13: 104
    CrossrefPubMedGoogle Scholar
  • 27 Elimian A, Figueroa R, Spitzer AR, Ogburn PL, Wiencek V, Quirk JG. Antenatal corticosteroids: are incomplete courses beneficial?. Obstet Gynecol 2003; 102 (2) 352-355
    CrossrefPubMedGoogle Scholar
  • 28 Foix-L'Hélias L, Marret S, Ancel PY , et al; EPIPAGE Study Group. Impact of the use of antenatal corticosteroids on mortality, cerebral lesions and 5-year neurodevelopmental outcomes of very preterm infants: the EPIPAGE cohort study. BJOG 2008; 115 (2) 275-282
    PubMedGoogle Scholar
  • 29 Costa S, Zecca E, De Luca D, De Carolis MP, Romagnoli C. Efficacy of a single dose of antenatal corticosteroids on morbidity and mortality of preterm infants. Eur J Obstet Gynecol Reprod Biol 2007; 131 (2) 154-157
    CrossrefPubMedGoogle Scholar
  • 30 Sen S, Reghu A, Ferguson SD. Efficacy of a single dose of antenatal steroid in surfactant-treated babies under 31 weeks' gestation. J Matern Fetal Neonatal Med 2002; 12 (5) 298-303
    CrossrefPubMedGoogle Scholar
  • 31 Sehdev HM, Abbasi S, Robertson P , et al. The effects of the time interval from antenatal corticosteroid exposure to delivery on neonatal outcome of very low birth weight infants. Am J Obstet Gynecol 2004; 191 (4) 1409-1413
    CrossrefPubMedGoogle Scholar
  • 32 Wong D, Abdel-Latif M, Kent A ; NICUS Network. Antenatal steroid exposure and outcomes of very premature infants: a regional cohort study. Arch Dis Child Fetal Neonatal Ed 2014; 99 (1) F12-F20
    CrossrefPubMedGoogle Scholar
  • 33 Balci O, Ozdemir S, Mahmoud AS, Acar A, Colakoglu MC. The effect of antenatal steroids on fetal lung maturation between the 34th and 36th week of pregnancy. Gynecol Obstet Invest 2010; 70 (2) 95-99
    CrossrefPubMedGoogle Scholar
  • 34 Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Am J Obstet Gynecol 2009; 201 (6) e1-e7
    PubMedGoogle Scholar
  • 35 Jobe AH, Soll RF. Choice and dose of corticosteroid for antenatal treatments. Am J Obstet Gynecol 2004; 190 (4) 878-881
    CrossrefPubMedGoogle Scholar
  • 36 McLaughlin KJ, Crowther CA, Walker N, Harding JE. Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review. Aust N Z J Obstet Gynaecol 2003; 43 (2) 101-106
    CrossrefPubMedGoogle Scholar
  • 37 Vis JY, Wilms FF, Kuin RA , et al. Time to delivery after the first course of antenatal corticosteroids: a cohort study. Am J Perinatol 2011; 28 (9) 683-688
    Article in Thieme ConnectPubMedGoogle Scholar
  • 38 Davidson C, Monga M, Ellison D, Vidaeff A. Continuation of pregnancy after antenatal corticosteroid administration: opportunity for rescue?. J Reprod Med 2010; 55 (1-2) 14-18
    PubMedGoogle Scholar
  • 39 McLaughlin KJ, Crowther CA, Vigneswaran P, Hancock E, Willson K. Who remains undelivered more than seven days after a single course of prenatal corticosteroids and gives birth at less than 34 weeks?. Aust N Z J Obstet Gynaecol 2002; 42 (4) 353-357
    CrossrefPubMedGoogle Scholar
  • 40 McEvoy C, Schilling D, Spitale P, Peters D, O'Malley J, Durand M. Decreased respiratory compliance in infants less than or equal to 32 weeks' gestation, delivered more than 7 days after antenatal steroid therapy. Pediatrics 2008; 121 (5) e1032-e1038
    CrossrefPubMedGoogle Scholar
  • 41 Peaceman AM, Bajaj K, Kumar P, Grobman WA. The interval between a single course of antenatal steroids and delivery and its association with neonatal outcomes. Am J Obstet Gynecol 2005; 193 (3 Pt 2) 1165-1169
    CrossrefPubMedGoogle Scholar
  • 42 Waters TP, Mercer B. Impact of timing of antenatal corticosteroid exposure on neonatal outcomes. J Matern Fetal Neonatal Med 2009; 22 (4) 311-314
    CrossrefPubMedGoogle Scholar
  • 43 Ring AM, Garland JS, Stafeil BR, Carr MH, Peckman GS, Pircon RA. The effect of a prolonged time interval between antenatal corticosteroid administration and delivery on outcomes in preterm neonates: a cohort study. Am J Obstet Gynecol 2007; 196 (5) e1-e6
    PubMedGoogle Scholar
  • 44 Crowther CA, Haslam RR, Hiller JE, Doyle LW, Robinson JS ; Australasian Collaborative Trial of Repeat Doses of Steroids (ACTORDS) Study Group. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet 2006; 367 (9526) 1913-1919
    CrossrefPubMedGoogle Scholar
  • 45 Guinn DA, Atkinson MW, Sullivan L , et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: A randomized controlled trial. JAMA 2001; 286 (13) 1581-1587
    CrossrefPubMedGoogle Scholar
  • 46 Pratt L, Magness RR, Phernetton T, Hendricks SK, Abbott DH, Bird IM. Repeated use of betamethasone in rabbits: effects of treatment variation on adrenal suppression, pulmonary maturation, and pregnancy outcome. Am J Obstet Gynecol 1999; 180 (4) 995-1005
    CrossrefPubMedGoogle Scholar
  • 47 Shelton SD, Boggess KA, Murtha AP, Groff AO, Herbert WN. Repeated fetal betamethasone treatment and birth weight and head circumference. Obstet Gynecol 2001; 97 (2) 301-304
    CrossrefPubMedGoogle Scholar
  • 48 Murphy KE, Hannah ME, Willan AR , et al; MACS Collaborative Group. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 2008; 372 (9656) 2143-2151
    Google Scholar
  • 49 Wapner RJ, Sorokin Y, Thom EA , et al; National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 2006; 195 (3) 633-642
    CrossrefPubMedGoogle Scholar
  • 50 Abbasi S, Hirsch D, Davis J , et al. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol 2000; 182 (5) 1243-1249
    CrossrefPubMedGoogle Scholar
  • 51 Banks BA, Cnaan A, Morgan MA , et al; North American Thyrotropin-Releasing Hormone Study Group. Multiple courses of antenatal corticosteroids and outcome of premature neonates. Am J Obstet Gynecol 1999; 181 (3) 709-717
    CrossrefPubMedGoogle Scholar
  • 52 Bloom SL, Sheffield JS, McIntire DD, Leveno KJ. Antenatal dexamethasone and decreased birth weight. Obstet Gynecol 2001; 97 (4) 485-490
    CrossrefPubMedGoogle Scholar
  • 53 Crowther CA, Doyle LW, Haslam RR, Hiller JE, Harding JE, Robinson JS ; ACTORDS Study Group. Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med 2007; 357 (12) 1179-1189
    CrossrefPubMedGoogle Scholar
  • 54 Aghajafari F, Murphy K, Willan A , et al. Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis. Am J Obstet Gynecol 2001; 185 (5) 1073-1080
    CrossrefPubMedGoogle Scholar
  • 55 Jobe AH, Newnham J, Willet K, Sly P, Ikegami M. Fetal versus maternal and gestational age effects of repetitive antenatal glucocorticoids. Pediatrics 1998; 102 (5) 1116-1125
    CrossrefPubMedGoogle Scholar
  • 56 Vermillion ST, Soper DE, Newman RB. Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy. Am J Obstet Gynecol 2000; 183 (4) 810-814
    CrossrefPubMedGoogle Scholar
  • 57 Aghajafari F, Murphy K, Matthews S, Ohlsson A, Amankwah K, Hannah M. Repeated doses of antenatal corticosteroids in animals: a systematic review. Am J Obstet Gynecol 2002; 186 (4) 843-849
    CrossrefPubMedGoogle Scholar
  • 58 Murphy KE, Willan AR, Hannah ME , et al; Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group. Effect of antenatal corticosteroids on fetal growth and gestational age at birth. Obstet Gynecol 2012; 119 (5) 917-923
    CrossrefPubMedGoogle Scholar
  • 59 Crowther CA, McKinlay CJ, Middleton P, Harding JE. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. Cochrane Database Syst Rev 2011; (6) CD003935
    PubMedGoogle Scholar
  • 60 Asztalos EV, Murphy KE, Willan AR , et al; MACS-5 Collaborative Group. Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5). JAMA Pediatr 2013; 167 (12) 1102-1110
    PubMedGoogle Scholar
  • 61 Asztalos E, Willan A, Murphy K , et al; MACS-5 Collaborative Group. Association between gestational age at birth, antenatal corticosteroids, and outcomes at 5 years: multiple courses of antenatal corticosteroids for preterm birth study at 5 years of age (MACS-5). BMC Pregnancy Childbirth 2014; 14 (1) 272
    CrossrefPubMedGoogle Scholar
  • 62 McEvoy C, Schilling D, Peters D , et al. Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial. Am J Obstet Gynecol 2010; 202 (6) e1-e9
    PubMedGoogle Scholar
  • 63 Garite TJ, Kurtzman J, Maurel K, Clark R ; Obstetrix Collaborative Research Network. Impact of a ‘rescue course’ of antenatal corticosteroids: a multicenter randomized placebo-controlled trial. Am J Obstet Gynecol 2009; 200 (3) e1-e9
    PubMedGoogle Scholar
  • 64 Vermillion ST, Bland ML, Soper DE. Effectiveness of a rescue dose of antenatal betamethasone after an initial single course. Am J Obstet Gynecol 2001; 185 (5) 1086-1089
    CrossrefPubMedGoogle Scholar
  • 65 Peltoniemi OM, Kari MA, Tammela O , et al; Repeat Antenatal Betamethasone Study Group. Randomized trial of a single repeat dose of prenatal betamethasone treatment in imminent preterm birth. Pediatrics 2007; 119 (2) 290-298
    CrossrefPubMedGoogle Scholar
  • 66 Sanchez-Ramos L, Delke I, Zamora J, Kaunitz AM. Fetal fibronectin as a short-term predictor of preterm birth in symptomatic patients: a meta-analysis. Obstet Gynecol 2009; 114 (3) 631-640
    CrossrefPubMedGoogle Scholar
  • 67 Sotiriadis A, Papatheodorou S, Kavvadias A, Makrydimas G. Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta-analysis. Ultrasound Obstet Gynecol 2010; 35 (1) 54-64
    CrossrefPubMedGoogle Scholar
  • 68 van Baaren GJ, Vis JY, Wilms FF , et al. Predictive value of cervical length measurement and fibronectin testing in threatened preterm labor. Obstet Gynecol 2014; 123 (6) 1185-1192
    CrossrefPubMedGoogle Scholar
  • 69 Boots AB, Sanchez-Ramos L, Bowers DM, Kaunitz AM, Zamora J, Schlattmann P. The short-term prediction of preterm birth: a systematic review and diagnostic metaanalysis. Am J Obstet Gynecol 2014; 210 (1) e1-e10
    PubMedGoogle Scholar
  • 70 Abbott DS, Radford SK, Seed PT, Tribe RM, Shennan AH. Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women. Am J Obstet Gynecol 2013; 208 (2) e1-e6
    PubMedGoogle Scholar
  • 71 Costeloe K, Hennessy E, Gibson AT, Marlow N, Wilkinson AR. The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics 2000; 106 (4) 659-671
    CrossrefPubMedGoogle Scholar
  • 72 Tyson JE, Parikh NA, Langer J, Green C, Higgins RD ; National Institute of Child Health and Human Development Neonatal Research Network. Intensive care for extreme prematurity—moving beyond gestational age. N Engl J Med 2008; 358 (16) 1672-1681
    CrossrefPubMedGoogle Scholar
  • 73 Crowley P, Chalmers I, Keirse MJ. The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Br J Obstet Gynaecol 1990; 97 (1) 11-25
    CrossrefPubMedGoogle Scholar
  • 74 Gultom E, Doyle LW, Davis P, Dharmalingam A, Bowman E. Changes over time in attitudes to treatment and survival rates for extremely preterm infants (23-27 weeks' gestational age). Aust N Z J Obstet Gynaecol 1997; 37 (1) 56-58
    CrossrefPubMedGoogle Scholar
  • 75 Jobe AH. Lung development and maturation. In: Martin RJ, Fanaroff AA, Walsh MC, , eds. Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 9th ed. Philadelphia: Mosby/Elsevier; 2011: 1075-1092
    CrossrefGoogle Scholar
  • 76 Onland W, de Laat MW, Mol BW, Offringa M. Effects of antenatal corticosteroids given prior to 26 weeks' gestation: a systematic review of randomized controlled trials. Am J Perinatol 2011; 28 (1) 33-44
    Article in Thieme ConnectPubMedGoogle Scholar
  • 77 Herber-Jonat S, Schulze A, Kribs A, Roth B, Lindner W, Pohlandt F. Survival and major neonatal complications in infants born between 22 0/7 and 24 6/7 weeks of gestation (1999-2003). Am J Obstet Gynecol 2006; 195 (1) 16-22
    CrossrefPubMedGoogle Scholar
  • 78 Hayes EJ, Paul DA, Stahl GE , et al. Effect of antenatal corticosteroids on survival for neonates born at 23 weeks of gestation. Obstet Gynecol 2008; 111 (4) 921-926
    CrossrefPubMedGoogle Scholar
  • 79 Malloy MH. Antenatal steroid use and neonatal outcome: United States 2007. J Perinatol 2012; 32 (9) 722-727
    CrossrefPubMedGoogle Scholar
  • 80 Abbasi S, Oxford C, Gerdes J, Sehdev H, Ludmir J. Antenatal corticosteroids prior to 24 weeks' gestation and neonatal outcome of extremely low birth weight infants. Am J Perinatol 2010; 27 (1) 61-66
    Article in Thieme ConnectPubMedGoogle Scholar
  • 81 Carlo WA, McDonald SA, Fanaroff AA , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. JAMA 2011; 306 (21) 2348-2358
    CrossrefPubMedGoogle Scholar
  • 82 Mori R, Kusuda S, Fujimura M ; Neonatal Research Network Japan. Antenatal corticosteroids promote survival of extremely preterm infants born at 22 to 23 weeks of gestation. J Pediatr 2011; 159 (1) 110-114 , e1
    Google Scholar
  • 83 Manktelow BN, Lal MK, Field DJ, Sinha SK. Antenatal corticosteroids and neonatal outcomes according to gestational age: a cohort study. Arch Dis Child Fetal Neonatal Ed 2010; 95 (2) F95-F98
    CrossrefPubMedGoogle Scholar
  • 84 Jobe AH. “Miracle” extremely low birth weight neonates: examples of developmental plasticity. Obstet Gynecol 2010; 116 (5) 1184-1190
    CrossrefPubMedGoogle Scholar
  • 85 Davidoff MJ, Dias T, Damus K , et al. Changes in the gestational age distribution among U.S. singleton births: impact on rates of late preterm birth, 1992 to 2002. Semin Perinatol 2006; 30 (1) 8-15
    CrossrefPubMedGoogle Scholar
  • 86 Raju TN. The problem of late-preterm (near-term) births: a workshop summary. Pediatr Res 2006; 60 (6) 775-776
    CrossrefPubMedGoogle Scholar
  • 87 McIntire DD, Leveno KJ. Neonatal mortality and morbidity rates in late preterm births compared with births at term. Obstet Gynecol 2008; 111 (1) 35-41
    CrossrefPubMedGoogle Scholar
  • 88 Teune MJ, Bakhuizen S, Gyamfi Bannerman C , et al. A systematic review of severe morbidity in infants born late preterm. Am J Obstet Gynecol 2011; 205 (4) e1-e9
    CrossrefPubMedGoogle Scholar
  • 89 Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near-term infants. Pediatrics 2004; 114 (2) 372-376
    CrossrefPubMedGoogle Scholar
  • 90 Escobar GJ, Clark RH, Greene JD. Short-term outcomes of infants born at 35 and 36 weeks gestation: we need to ask more questions. Semin Perinatol 2006; 30 (1) 28-33
    CrossrefPubMedGoogle Scholar
  • 91 Engle WA, Tomashek KM, Wallman C ; Committee on Fetus and Newborn, American Academy of Pediatrics. “Late-preterm” infants: a population at risk. Pediatrics 2007; 120 (6) 1390-1401
    CrossrefPubMedGoogle Scholar
  • 92 Gilbert WM, Nesbitt TS, Danielsen B. The cost of prematurity: quantification by gestational age and birth weight. Obstet Gynecol 2003; 102 (3) 488-492
    CrossrefPubMedGoogle Scholar
  • 93 Jain L, Eaton DC. Physiology of fetal lung fluid clearance and the effect of labor. Semin Perinatol 2006; 30 (1) 34-43
    Google Scholar
  • 94 Eriksson L, Haglund B, Ewald U, Odlind V, Kieler H. Health consequences of prophylactic exposure to antenatal corticosteroids among children born late preterm or term. Acta Obstet Gynecol Scand 2012; 91 (12) 1415-1421
    CrossrefPubMedGoogle Scholar
  • 95 Porto AM, Coutinho IC, Correia JB, Amorim MM. Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial. BMJ 2011; 342: d1696
    CrossrefPubMedGoogle Scholar
  • 96 Ventolini G, Neiger R, Mathews L, Adragna N, Belcastro M. Incidence of respiratory disorders in neonates born between 34 and 36 weeks of gestation following exposure to antenatal corticosteroids between 24 and 34 weeks of gestation. Am J Perinatol 2008; 25 (2) 79-83
    Article in Thieme ConnectPubMedGoogle Scholar
  • 97 Shanks A, Gross G, Shim T, Allsworth J, Sadovsky Y, Bildirici I. Administration of steroids after 34 weeks of gestation enhances fetal lung maturity profiles. Am J Obstet Gynecol 2010; 203 (1) e1-e5
    CrossrefPubMedGoogle Scholar
  • 98 Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol 2012; 119 (5) 909-916
    CrossrefPubMedGoogle Scholar
  • 99 Ghidini A, Hicks C, Lapinski RH, Lockwood CJ. Morbidity in the preterm infant with mature lung indices. Am J Perinatol 1997; 14 (2) 75-78
    Article in Thieme ConnectPubMedGoogle Scholar
  • 100 Lewis DF, McCann J, Wang Y, Cormier C, Groome L. Hospitalized late preterm mild preeclamptic patients with mature lung testing: what are the risks of delivery?. J Perinatol 2009; 29 (6) 413-415
    CrossrefPubMedGoogle Scholar
  • 101 Loftin RW, Habli M, Snyder CC, Cormier CM, Lewis DF, Defranco EA. Late preterm birth. Rev Obstet Gynecol 2010; 3 (1) 10-19
    PubMedGoogle Scholar
  • 102 Hansen AK, Wisborg K, Uldbjerg N, Henriksen TB. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. BMJ 2008; 336 (7635) 85-87
    CrossrefPubMedGoogle Scholar
  • 103 Stutchfield P, Whitaker R, Russell I ; Antenatal Steroids for Term Elective Caesarean Section (ASTECS) Research Team. Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial. BMJ 2005; 331 (7518) 662
    CrossrefPubMedGoogle Scholar
  • 104 Stutchfield PR, Whitaker R, Gliddon AE, Hobson L, Kotecha S, Doull IJ. Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial). Arch Dis Child Fetal Neonatal Ed 2013; 98 (3) F195-F200
    CrossrefPubMedGoogle Scholar
  • 105 Sinclair JC. Meta-analysis of randomized controlled trials of antenatal corticosteroid for the prevention of respiratory distress syndrome: discussion. discussion Am J Obstet Gynecol 1995; 173 (1) 335-344
    PubMedGoogle Scholar
  • 106 Chauhan SP, Scardo JA, Hayes E, Abuhamad AZ, Berghella V. Twins: prevalence, problems, and preterm births. Am J Obstet Gynecol 2010; 203 (4) 305-315
    CrossrefPubMedGoogle Scholar
  • 107 Ananth CV, Chauhan SP. Epidemiology of twinning in developed countries. Semin Perinatol 2012; 36 (3) 156-161
    CrossrefPubMedGoogle Scholar
  • 108 Ananth CV, Friedman AM, Gyamfi-Bannerman C. Epidemiology of moderate preterm, late preterm and early term delivery. Clin Perinatol 2013; 40 (4) 601-610
    CrossrefPubMedGoogle Scholar
  • 109 Hashimoto LN, Hornung RW, Lindsell CJ, Brewer DE, Donovan EF. Effects of antenatal glucocorticoids on outcomes of very low birth weight multifetal gestations. Am J Obstet Gynecol 2002; 187 (3) 804-810
    CrossrefPubMedGoogle Scholar
  • 110 Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371 (9606) 75-84
    CrossrefPubMedGoogle Scholar
  • 111 NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 1995; 273 (5) 413-418
    CrossrefPubMedGoogle Scholar
  • 112 Turrentine MA, Wilson PD, Wilkins IA. A retrospective analysis of the effect of antenatal steroid administration on the incidence of respiratory distress syndrome in preterm twin pregnancies. Am J Perinatol 1996; 13 (6) 351-354
    Article in Thieme ConnectPubMedGoogle Scholar
  • 113 Choi SJ, Song SE, Seo ES, Oh SY, Kim JH, Roh CR. The effect of single or multiple courses of antenatal corticosteroid therapy on neonatal respiratory distress syndrome in singleton versus twin pregnancies. Aust N Z J Obstet Gynaecol 2009; 49 (2) 173-179
    CrossrefPubMedGoogle Scholar
  • 114 Murphy DJ, Caukwell S, Joels LA, Wardle P. Cohort study of the neonatal outcome of twin pregnancies that were treated with prophylactic or rescue antenatal corticosteroids. Am J Obstet Gynecol 2002; 187 (2) 483-488
    CrossrefPubMedGoogle Scholar
  • 115 Battista L, Winovitch KC, Rumney PJ, Davis E, Hagemann C, Wing DA. A case-control comparison of the effectiveness of betamethasone to prevent neonatal morbidity and mortality in preterm twin and singleton pregnancies. Am J Perinatol 2008; 25 (7) 449-453
    Article in Thieme ConnectPubMedGoogle Scholar
  • 116 Spinillo A, Capuzzo E, Ometto A, Stronati M, Baltaro F, Iasci A. Value of antenatal corticosteroid therapy in preterm birth. Early Hum Dev 1995; 42 (1) 37-47
    CrossrefPubMedGoogle Scholar
  • 117 Al-Yatama MK, Al Essa M, Omu AE, Al-Shamali I, Egbase P, Rashwan N. Effect of repeated doses of dexamethasone on the incidence and severity of respiratory distress syndrome in multifetal gestation between 24 and 34 weeks. Gynecol Obstet Invest 2001; 52 (1) 26-33
    CrossrefPubMedGoogle Scholar
  • 118 Blickstein I, Shinwell ES, Lusky A, Reichman B ; Israel Neonatal Network. Plurality-dependent risk of respiratory distress syndrome among very-low-birth-weight infants and antepartum corticosteroid treatment. Am J Obstet Gynecol 2005; 192 (2) 360-364
    CrossrefPubMedGoogle Scholar
  • 119 Kuk JY, An JJ, Cha HH , et al. Optimal time interval between a single course of antenatal corticosteroids and delivery for reduction of respiratory distress syndrome in preterm twins. Am J Obstet Gynecol 2013; 209 (3) e1-e7
    PubMedGoogle Scholar
  • 120 Blickstein I, Reichman B, Lusky A, Shinwell ES ; Israel Neonatal Network. Plurality-dependent risk of severe intraventricular hemorrhage among very low birth weight infants and antepartum corticosteroid treatment. Am J Obstet Gynecol 2006; 194 (5) 1329-1333
    CrossrefPubMedGoogle Scholar
  • 121 Waters T, Hoffman M, Daly S, Sloan J, Sheridan-Pereira M. Newborn anthropometric measurements in twin pregnancies exposed to multiple courses of antenatal steroids. Am J Obstet Gynecol 2005; 193 (6 Suppl): S63
    PubMedGoogle Scholar
  • 122 Bibbo C, Deluca L, Gibbs KA , et al. Rescue corticosteroids in twin pregnancies and short-term neonatal outcomes. BJOG 2013; 120 (1) 58-63
    CrossrefPubMedGoogle Scholar
  • 123 Ballabh P, Lo ES, Kumari J , et al. Pharmacokinetics of betamethasone in twin and singleton pregnancy. Clin Pharmacol Ther 2002; 71 (1) 39-45
    CrossrefPubMedGoogle Scholar
  • 124 Della Torre M, Hibbard JU, Jeong H, Fischer JH. Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics. Am J Obstet Gynecol 2010; 203 (3) e1-e12
    CrossrefPubMedGoogle Scholar
  • 125 Gyamfi C, Mele L, Wapner RJ , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery. Am J Obstet Gynecol 2010; 203 (3) e1-e5
    CrossrefPubMedGoogle Scholar
  • 126 Mulder EJ, Derks JB, Visser GH. Effects of antenatal betamethasone administration on fetal heart rate and behavior in twin pregnancy. Pediatr Res 2004; 56 (1) 35-39
    CrossrefPubMedGoogle Scholar
  • 127 Jobe AH, Ikegami M. Lung development and function in preterm infants in the surfactant treatment era. Annu Rev Physiol 2000; 62: 825-846
    CrossrefPubMedGoogle Scholar
  • 128 Jobe AH. Antenatal steroids in twins. Am J Obstet Gynecol 2003; 188 (3) 856 , author reply 857
    CrossrefPubMedGoogle Scholar
  • 129 Quist-Therson EC, Myhr TL, Ohlsson A. Antenatal steroids to prevent respiratory distress syndrome: multiple gestation as an effect modifier. Acta Obstet Gynecol Scand 1999; 78 (5) 388-392
    CrossrefPubMedGoogle Scholar