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J Knee Surg 2016; 29(02): 159-168
DOI: 10.1055/s-0034-1395281
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Delayed Total Knee Replacement with Hylan G-F 20

David D. Waddell
1   Orthopedic Specialists of Louisiana, Shreveport, Louisiana
,
Biji Joseph
2   Sanofi, Cambridge, Massachusetts
› Author Affiliations
Further Information

Publication History

12 August 2014

23 September 2014

Publication Date:
28 October 2014 (online)

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Abstract

We retrospectively examined prospective data on the incidence and time to total knee replacement (TKR) in (1) patients with grade IV osteoarthritis (OA) treated with hylan G-F 20 from 1997 to 2010 (full cohort; 1,863 knees) and (2) a patient subset treated from 1997 to 2003 (original cohort; 1,187 knees) to determine any continued hylan G-F 20 influence on TKR delay. In both the cohorts, 25 to 28% knees underwent a TKR, with an average of 2.8 to 3.1 years occurring between hylan G-F 20 and surgery. Age was a significant predictor of time to TKR. Knee synovitis increased slightly with repeat courses; most cases considered mild or moderate. Survival analysis showed that TKR was delayed for > 7 years in 75% of 1,863 grade IV OA knees (1,342 patients) treated with hylan G-F 20 in an orthopedic practice. Consistent with our previous report (Waddell and Bricker, 2007), we show hylan G-F 20 continues to delay the need for TKR.

Keywords

hylan G-F 20 - knee - osteoarthritis - pain - total knee replacement
 

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