Moderne bildgebende Verfahren im Management 
der pulmonalen Hypertonie

G. Kovacs; M. Pienn; E. Grünig; D. Mereles; M. Claussen; M. Dandel; D. Dumitrescu; I. Kruck; L. Bruch; R. Blindt; S. Holt; L. Sinn; S. Sorichter; J. Winkler; H. Olschewski

doi:10.1055/s-0034-1387484

DMW - Deutsche Medizinische Wochenschrift, Table of Contents

Dtsch Med Wochenschr 2014; 139(S 04): S121-S125
DOI: 10.1055/s-0034-1387484

Übersicht | Review article

Pneumologie

Moderne bildgebende Verfahren im Management der pulmonalen Hypertonie

Modern imaging methods in the management of pulmonary hypertension

G. Kovacs

¹Abt. für Pneumologie, Universitätsklinikum Graz, Österreich

²Ludwig Boltzmann Institut für Lungengefäßforschung, Graz, Österreich

,

M. Pienn

²Ludwig Boltzmann Institut für Lungengefäßforschung, Graz, Österreich

,

E. Grünig

³Zentrum für pulmonale Hypertonie, Thoraxklinik am Universitätsklinikum Heidelberg, Deutschland

,

D. Mereles

⁴Abt. Kardiologie, Medizinische Universitätsklinik Heidelberg, Deutschland

,

M. Claussen

⁵LungenClinic Großhansdorf, Deutschland

,

M. Dandel

⁶Deutsches Herzzentrum Berlin, Deutschland

,

D. Dumitrescu

⁷Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Deutschland

,

I. Kruck

⁸Cardio-Centrum Ludwigsburg Bietigheim, Ludwigsburg, Deutschland

,

L. Bruch

⁹Abt. Kardiologie, Klinik für Innere Medizin, Unfallkrankenhaus Berlin

,

R. Blindt

¹⁰Kardio Bremen, kardiovaskuläres Zentrum, Bremen, Deutschland

,

S. Holt

¹¹Bethanien Krankenhaus Solingen, Institut für Pneumologie der Universität Witten/Herdecke Solingen, Deutschland

,

L. Sinn

¹²Kardiologische Praxis Bad Säckingen, Deutschland

,

S. Sorichter

¹³Klinik für Pneumologie im St. Josefskrankenhaus, Freiburg, Deutschland

,

J. Winkler

¹⁴Praxis für Pneumologie, Leipzig, Deutschland

,

H. Olschewski

¹Abt. für Pneumologie, Universitätsklinikum Graz, Österreich

²Ludwig Boltzmann Institut für Lungengefäßforschung, Graz, Österreich

› Author Affiliations

Abstract

Schlüsselwörter

Pulmonale Hypertonie - Diagnostik - Echokardiographie - Computertomographie - Kernspintomographie

Keywords

pulmonary hypertension - diagnosis - echocardiography - computertomography - magnetic resonance imaging

Full Text

References

Referenzen
1 Hoeper MM, Bogaard HJ, Condliffe R et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol 2013; 62 (Suppl. 25) D42-50
2 Condliffe R, Kiely DG, Peacock AJ et al. Connective tissue disease-associated pulmonary arterial hypertension in the modern treatment era. Am J Respir Crit Care Med 2009; 179: 151-7
3 Kovacs G, Maier R, Aberer E et al. Borderline pulmonary arterial pressure is associated with decreased exercise capacity in scleroderma. Am J Respir Crit Care Med 2009; 180: 881-6
4 Argiento P, Vanderpool RR, Mule M et al. Exercise stress echocardiography of the pulmonary circulation: limits of normal and sex differences. Chest 2012; 142: 1158-65
5 Naeije R, Vanderpool R, Dhakal BP et al. Exercise-induced pulmonary hypertension: physiological basis and methodological concerns. Am J Respir Crit Care Med 2013; 187: 576-83
6 Lewis GD, Bossone E, Naeije R et al. Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases. Circulation 2013; 128: 1470-9
7 Chemla D, Castelain V, Humbert M et al. New formula for predicting mean pulmonary artery pressure using systolic pulmonary artery pressure. Chest 2004; 126: 1313-7
8 Kovacs G, Maier R, Aberer E et al. Assessment of pulmonary arterial pressure during exercise in collagen vascular disease: echocardiography vs right-sided heart catheterization. Chest 2010; 138: 270-8
9 Grunig E, Tiede H, Enyimayew EO et al. Assessment and prognostic relevance of right ventricular contractile reserve in patients with severe pulmonary hypertension. Circulation 2013; 128: 2005-15
10 Grunig E, Janssen B, Mereles D et al. Abnormal pulmonary artery pressure response in asymptomatic carriers of primary pulmonary hypertension gene. Circulation 2000; 102: 1145-50
11 Grunig E, Weissmann S, Ehlken N et al. Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. Circulation 2009; 119: 1747-57
12 Hinderhofer K, Fischer C, Pfarr N et al. Identification of a new intronic BMPR2-mutation and early diagnosis of heritable pulmonary arterial hypertension in a large family with mean clinical follow-up of 12 years. PLoS One 2014; 9: e91374
13 Sachdev A, Villarraga HR, Frantz RP et al. Right ventricular strain for prediction of survival in patients with pulmonary arterial hypertension. Chest 2011; 139: 1299-309
14 Haeck ML, Scherptong RW, Marsan NA et al. Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Circulation Cardiovascular Imaging 2012; 5: 628-36
15 Freed BH, Tsang W, Bhave NM et al. Right Ventricular Strain in Pulmonary Arterial Hypertension: A 2D Echocardiography and Cardiac Magnetic Resonance Study. Echocardiography (Mount Kisco, NY) 2014;
16 Rajagopalan N, Saxena N, Simon MA et al. Correlation of tricuspid annular velocities with invasive hemodynamics in pulmonary hypertension. Congestive heart failure (Greenwich, Conn) 2007; 13: 200-4
17 Ernande L, Cottin V, Leroux PY et al. Right isovolumic contraction velocity predicts survival in pulmonary hypertension. J Am Soc Echocardiogr 2013; 26: 297-306
18 Li Y, Xie M, Wang X et al. Right ventricular regional and global systolic function is diminished in patients with pulmonary arterial hypertension: a 2-dimensional ultrasound speckle tracking echocardiography study. Int J Cardiovasc Imaging 2013; 29: 545-51
19 Smith BC, Dobson G, Dawson D et al. Three-dimensional speckle tracking of the right ventricle: toward optimal quantification of right ventricular dysfunction in pulmonary hypertension. J AmColl Cardiol 2014; 64: 41-51
20 Lopez-Candales A, Lopez FR, Trivedi S et al. Right ventricular ejection efficiency: a new echocardiographic measure of mechanical performance in chronic pulmonary hypertension. Echocardiography 2014; 31: 516-23
21 Grapsa J, Gibbs JS, Cabrita IZ et al. The association of clinical outcome with right atrial and ventricular remodelling in patients with pulmonary arterial hypertension: study with real-time three-dimensional echocardiography. European heart journal cardiovascular Imaging 2012; 13: 666-72
22 Zhang QB, Sun JP, Gao RF et al. Feasibility of single-beat full-volume capture real-time three-dimensional echocardiography for quantification of right ventricular volume: validation by cardiac magnetic resonance imaging. Inte J Cardiol 2013; 168: 3991-5
23 Kovacs G, Berghold A, Scheidl S et al. Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. Eur Respir J 2009; 34: 888-94
24 Kovacs G, Olschewski A, Berghold A et al. Pulmonary vascular resistances during exercise in normal subjects: a systematic review. Eur Respir J 2012; 39: 319-28
25 D'Andrea A, Naeije R, Grunig E et al. Echocardiography of the pulmonary circulation and right ventricular function: exploring the physiologic spectrum in 1,480 normal subjects. Chest 2014; 145: 1071-8
26 Grunig E, Henn P, D'Andrea A et al. Reference values for and determinants of right atrial area in healthy adults by 2-dimensional echocardiography. Circ Cardiovasc Imaging 2013; 6: 117-24
27 Coghlan JG, Denton CP, Grunig E et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 2014; 73: 1340-9
28 Fisher MR, Forfia PR, Chamera E et al. Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med 2009; 179: 615-21
29 Greiner S, Jud A, Aurich M et al. Reliability of noninvasive assessment of systolic pulmonary artery pressure by Doppler echocardiography compared to right heart catheterization: analysis in a large patient population. J Am Heart Assoc 2014; 3
30 Truong QA, Massaro JM, Rogers IS et al. Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study. Circulation Cardiovasc Imaging 2012; 5: 147-54
31 Dornia C, Lange TJ, Behrens G et al. Multidetector computed tomography for detection and characterization of pulmonary hypertension in consideration of WHO classification. J Comp Assist Tomogr 2012; 36: 175-80
32 Iyer AS, Wells JM, Vishin S et al. CT scan-measured pulmonary artery to aorta ratio and echocardiography for detecting pulmonary hypertension in severe COPD. Chest 2014; 145: 824-32
33 Helmberger M, Pienn M, Urschler M et al. Quantification of tortuosity and fractal dimension of the lung vessels in pulmonary hypertension patients. PLoS One 2014; 9: e87515
34 Hoey ET, Gopalan D, Agrawal SK et al. Cardiac causes of pulmonary arterial hypertension: assessment with multidetector CT. European Radiology 2009; 19: 2557-68
35 Pienn M, Kovacs G, Tscherner M et al. Determination of cardiac output with dynamic contrast-enhanced computed tomography. Int J Cardiovasc Imaging 2013; 29: 1871-8
36 Pienn M, Kovacs G, Tscherner M et al. Non-invasive determination of pulmonary hypertension with dynamic contrast-enhanced computed tomography: a pilot study. European radiology 2014; 24: 668-76
37 Kovacs G, Reiter G, Reiter U et al. The emerging role of magnetic resonance imaging in the diagnosis and management of pulmonary hypertension. Respiration; Int RevThorac Dis 2008; 76: 458-70
38 Peacock AJ, Crawley S, McLure L et al. Changes in right ventricular function measured by cardiac magnetic resonance imaging in patients receiving pulmonary arterial hypertension-targeted therapy: the EURO-MR study. Circulation Cardiovasc Imaging 2014; 7: 107-14
39 Rajaram S, Swift AJ, Telfer A et al. 3D contrast-enhanced lung perfusion MRI is an effective screening tool for chronic thromboembolic pulmonary hypertension: results from the ASPIRE Registry. Thorax 2013; 68: 677-8
40 Wirth G, Bruggemann K, Bostel T et al. Chronic thromboembolic pulmonary hypertension (CTEPH) – potential role of multidetector-row CT (MD-CT) and MR imaging in the diagnosis and differential diagnosis of the disease. RoFo 2014; 186: 751-61
41 Reiter U, Reiter G, Kovacs G et al. Evaluation of elevated mean pulmonary arterial pressure based on magnetic resonance 4D velocity mapping: comparison of visualization techniques. PLoS One 2013; 8: e82212
42 Kreitner KF, Wirth GM, Krummenauer F et al. Noninvasive assessment of pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension by high temporal resolution phase-contrast MRI: correlation with simultaneous invasive pressure recordings. Circulation Cardiovasc Imaging 2013; 6: 722-9
43 Swift AJ, Rajaram S, Hurdman J et al. Noninvasive estimation of PA pressure, flow, and resistance with CMR imaging: derivation and prospective validation study from the ASPIRE registry. JACC Cardiovasc Imaging 2013; 6: 1036-47
44 Oikawa M, Kagaya Y, Otani H et al. Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. J Am Coll Cardiol 2005; 45: 1849-55
45 Marsboom G, Wietholt C, Haney CR et al. Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med 2012; 185: 670-9
46 Wang L, Zhang Y, Yan C et al. Evaluation of right ventricular volume and ejection fraction by gated (18)F-FDG PET in patients with pulmonary hypertension: comparison with cardiac MRI and CT. J Nucl Cardiol 2013; 20: 242-52
47 Tatebe S, Fukumoto Y, Oikawa-Wakayama M et al. Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study. Europ Heart J Cardiovasc Imaging 2014; 15: 666-72
48 Lau EM, Bailey DL, Bailey EA et al. Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: a SPECT/CT study. Heart 2014; 100: 47-53