Synlett 2015; 26(10): 1417-1421
DOI: 10.1055/s-0034-1380514
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© Georg Thieme Verlag Stuttgart · New York

Silver-Prompted Carbonitration of Acrylamides for the Synthesis of Nitrating Oxindoles

Xiao-Hong Wei
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
,
Quan-Xiang Wu
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
,
Shang-Dong Yang*
a   State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
b   State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China   eMail: yangshd@lzu.edu.cn
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Publikationsverlauf

Received: 05. Februar 2015

Accepted after revision: 06. März 2015

Publikationsdatum:
02. April 2015 (online)


Abstract

A silver-prompted carbonitration of alkenes involving concomitant direct C–H functionalization and C–N bond formation to synthesize nitrating oxindoles has been developed. The CR TH2 receptor antagonist skeleton can be obtained from one of the products with further modification.

Supporting Information