Aryne-Mediated Arylation of the 3-Benzazepine Scaffold: One-Pot Synthesis of 1-Aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines

Kamal Nain Singh; Paramjit Singh; Esha Sharma; Manjot Kaur; Yadwinder Singh Deol

doi:10.1055/s-0034-1380453

Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(20): 3212-3220
DOI: 10.1055/s-0034-1380453

paper

Aryne-Mediated Arylation of the 3-Benzazepine Scaffold: One-Pot Synthesis of 1-Aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines

Kamal Nain Singh*

Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India eMail: kns@pu.ac.in

,

Paramjit Singh

Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India eMail: kns@pu.ac.in

,

Esha Sharma

Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India eMail: kns@pu.ac.in

,

Manjot Kaur

Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India eMail: kns@pu.ac.in

,

Yadwinder Singh Deol

Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India eMail: kns@pu.ac.in

› Institutsangaben

Abstract

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Abstract

The coupling of β-amino carbanions derived from 3-benzazepines with in situ generated arynes has been demonstrated as a convenient route for the direct synthesis of a variety of 1-aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines, including the biologically active drug molecule SCH 12679.

Key words

arylation - arynes - carbanions - nucleophilic addition - drugs

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Referenzen

References

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