Synthesis of the C6–C14 Fragment of Euphosalicin

Abstract

The synthesis of the C6–C14 fragment of euphosalicin, a highly oxygenated modified jatrophane diterpene, is described. Key steps in the preparation of this versatile intermediate are an Ireland–Claisen rearrangement and a Shibasaki direct asymmetric aldol reaction.

Key words

natural products - total synthesis - aldol reaction - rearrangement - hydrostannation

• References and Notes

• 1 Current address: Uwe Rinner, Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz, Austria.
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