Highly Diastereoselective Cobalt-Mediated C(sp³)–C(sp²) Cross-Coupling Reactions of Cyclic Halohydrins with (Hetero)Aryl Grignard Reagents

Abstract

The highly diastereoselective cobalt-mediated cross-coupling of cyclic tert-butyldimethylsilyl-protected iodohydrins or bromohydrins with (hetero)arylmagnesium reagents has been expanded further. The method can be applied to a broad range of electron-poor and electron-rich Grignard reagents, furnishing the respective functionalized trans-2-arylcycloalcohols with diastereomeric ratios up to 99:1.

Key words

cobalt - diastereoselectivity - cross-coupling - Grignard reagents - arenes

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