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Synlett 2015; 26(09): 1195-1200
DOI: 10.1055/s-0034-1380348
DOI: 10.1055/s-0034-1380348
letter
Synthesis and Antimicrobial/Cytotoxic Assessment of Ferrocenyl Oxazinanes, Oxazinan-2-ones, and Tetrahydropyrimidin-2-ones
Further Information
Publication History
Received: 12 January 2015
Accepted after revision: 16 February 2015
Publication Date:
19 March 2015 (online)
Abstract
3-Arylamino-1-ferrocenylpropan-1-ones, prepared through aza-Michael addition of aromatic amines to 1-ferrocenylpropenone, were transformed into the corresponding 1,3-amino alcohols upon NaBH4-mediated carbonyl reduction. The latter amino alcohols were deployed as eligible substrates for the synthesis of a variety of ferrocene-containing heterocycles including 1,3-oxazinanes, 1,3-oxazinan-2-ones, and tetrahydropyrimidin-2-ones, which were subsequently evaluated for their antimicrobial and cytotoxic activities.
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References and Notes
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