Synthesis 2015; 47(17): 2593-2598
DOI: 10.1055/s-0034-1379932
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Tricyclic 1,2,3-Triazolopyridines

Jessica J. Frick
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA   Email: schwarz.jacob@gene.com
,
Cuong Q. Ly
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA   Email: schwarz.jacob@gene.com
,
Jacob B. Schwarz*
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA   Email: schwarz.jacob@gene.com
› Author Affiliations
Further Information

Publication History

Received: 06 March 2015

Accepted after revision: 28 April 2015

Publication Date:
24 June 2015 (online)


Abstract

Novel tricyclic triazolopyridines were prepared in two steps from the requisite bicyclic 2-ketopyridines. In order to examine the scope of the process, a reliable route to the 2,3-dihydro-1,5-naphthyridin-4(1H)-one, 7,8-dihydro-5H-pyrido[3,2-b]azepin-9(6H)-one, 7,8-dihydrooxepino[3,2-b]pyridin-9(6H)-one, and 7,8-dihydro-5H-pyrido[3,2-c]azepin-9(6H)-one scaffolds was also established.

Supporting Information