Concise Three-Step Strategy for the Synthesis of 2-Benzoxepin-3(1H)-ones

Abstract

A short and efficient method was developed for the synthesis of 2-benzoxepin-3(1H)-ones. The synthetic sequence comprises of initial intermolecular Heck coupling, followed by reduction of the carbonyl functionality of the Heck product and finally base-induced intramolecular condensation. Notably, the final condensation may proceed by an interesting oxy-Michael addition, cycloreversion via double bond isomerization and intramolecular condensation.

Key words

palladium catalysis - Heck coupling - reduction - condensation - benzoxepinones

• References

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