Synlett 2015; 26(03): 404-407
DOI: 10.1055/s-0034-1379734
letter
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Catalyst-Free Synthesis of Substituted 1,2,4-Triazoles

Ganesh M. Shelke
a   Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031, India   Email: anilkumar@pilani.bits-pilani.ac.in
b   Department of Biology and Chemistry, Nipissing University, North Bay, ON P1B 8L7, Canada
,
V. Kameswara Rao
a   Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031, India   Email: anilkumar@pilani.bits-pilani.ac.in
,
Mukund Jha
b   Department of Biology and Chemistry, Nipissing University, North Bay, ON P1B 8L7, Canada
,
T. Stan Cameron
c   Department of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2, Canada
,
Anil Kumar*
a   Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031, India   Email: anilkumar@pilani.bits-pilani.ac.in
› Author Affiliations
Further Information

Publication History

Received: 25 October 2014

Accepted after revision: 16 November 2014

Publication Date:
07 January 2015 (online)


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Abstract

A simple, efficient, and mild method has been developed for the synthesis of substituted 1,2,4-triazoles from hydrazines and formamide under microwave irradiation. The reaction proceeds smoothly in the absence of a catalyst and shows excellent functional-group tolerance.

Supporting Information