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Synthesis 2015; 47(05): 692-700
DOI: 10.1055/s-0034-1379459
DOI: 10.1055/s-0034-1379459
paper
Palladium-Catalyzed Cross-Coupling between 7-Azaindoles and Reformatsky Reagents
Further Information
Publication History
Received: 17 September 2014
Accepted after revision: 23 October 2014
Publication Date:
16 December 2014 (online)
Abstract
The preparation of various 2-(7-azaindolyl)carboxylic esters by Pd-catalyzed coupling of Reformatsky reagents with TBDMS-protected 3-bromo-7-azaindoles leading to a wide range of arylated ester derivatives is reported. After removal of the protecting group, the corresponding free 2-(7-azaindolyl)carboxylic esters are obtained in satisfactory yields.
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