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Synfacts 2014; 10(11): 1191
DOI: 10.1055/s-0034-1379343
DOI: 10.1055/s-0034-1379343
Metal-Mediated Synthesis
Ketones from Carbon Dioxide and Organolithium or Grignard Reagents
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Oktober 2014 (online)
Significance
The authors report two complementary continuous flow systems using either stoichiometric amounts or an excess of CO2 for the preparation of ketones. Starting from organolithium or Grignard reagents, the described synthesis shows significant advantages over conventional batch conditions in suppressing undesired symmetric ketone and tertiary alcohol byproducts.
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Comment
The observation that in this reaction organolithium reagents are more reactive in Et2O than in THF is unprecedented. Furthermore, by integrating an in-line generation of organolithium or organomagnesium species, a telescoped one-flow process capable of preparing ketones in a modular fashion from simple precursors has been established.
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