Formal Acylamination of Nitroalkenes in Aqueous Medium for the Synthesis of 2-Aryl-3-nitro-2,3-dihydroquinolin-4(1H)-ones

Abstract

Formal acylamination of aromatic nitroalkenes with N-(2-aminobenzoyl)benzotriazoles in aqueous methanol results in the diastereoselective synthesis of 2-aryl-3-nitro-2,3-dihydroquinolin-4(1H)-ones. The aliphatic nitroalkenes, however, form the Michael addition product with benzotriazole.

Key words

acylamination - nitroalkenes - N-(2-aminobenzoyl)benzotriazole - 2-aryl-3-nitro-2,3-dihydroquinolin-4(1H)-one - diastereoselective

• References

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