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Synthesis 2015; 47(21): 3363-3370
DOI: 10.1055/s-0034-1378788
DOI: 10.1055/s-0034-1378788
paper
Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines
Authors
Further Information
Publication History
Received: 02 May 2015
Accepted after revision: 04 June 2015
Publication Date:
29 July 2015 (online)
Abstract
A mild and efficient silver-mediated synthesis of 2,3-dihydro-1,3-oxazin-4-ones through a formal [4+2] cycloaddition reaction of aldimines and acylketene intermediates is described. A variety of functionalized and potentially biologically relevant heterocycles have been accessed in moderate to high yields through this process.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378788.
- Supporting Information (PDF)
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