Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines

Abstract

A mild and efficient silver-mediated synthesis of 2,3-dihydro-1,3-oxazin-4-ones through a formal [4+2] cycloaddition reaction of aldimines and acylketene intermediates is described. A variety of functionalized and potentially biologically relevant heterocycles have been accessed in moderate to high yields through this process.

Key words

cycloaddition - heterocycles - imines - transition metals - acylation

• References

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