Chemo- and stereoselective total synthesis of the basic trichochrome skeleton is described
starting from o-aminothiophenol and maleic anhydride in very good overall yield. The process involves
the synthesis of the corresponding 1,4-benzothiazin-2-ylacetates followed by their
sulfuryl chloride induced dihalogenation–dehydrohalogenation and a second condensation
with o-aminothiophenol as key steps.
Key words
o-aminothiophenol - maleic anhydride - halogenation - condensations - trichochrome
framework
