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Synthesis 2014; 46(23): 3191-3198
DOI: 10.1055/s-0034-1378652
DOI: 10.1055/s-0034-1378652
paper
Transition-Metal-Catalyzed Synthesis of 1,3-Diynes and Ynamides from 2-Bromo-1-iodoalkenes
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Publication History
Received: 26 March 2014
Accepted after revision: 24 July 2014
Publication Date:
03 September 2014 (online)
Abstract
Diynes and ynamides are important products in chemical synthesis. An efficient palladium-catalyzed homocoupling reaction of 2-bromo-1-iodoalkenes to give 1,3-diynes has been developed. The reactions are conducted under convenient conditions and provide products in moderate to excellent yields. Moreover, ynamides were synthesized from 2-bromo-1-iodoalkenes and carbamates, and it is noteworthy that this reaction is catalyzed by nanoparticulate copper(I) oxide to give ynamides in high yields.
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10.1055/s-00000084.
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