RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2014; 10(9): 0893
DOI: 10.1055/s-0034-1378570
DOI: 10.1055/s-0034-1378570
Synthesis of Natural Products and Potential Drugs
Synthesis of the Antifungal Agent ASP9726
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. August 2014 (online)

Significance
An 11-step synthesis of the antifungal agent ASP9726 (13.8% overall) from the fermentation product FR901379 is described that is remarkable for the highly chemoselective transformations on functionally dense substrates.
MissingLinkText
Comment
The closing stages of the synthesis feature the reductive amination of primary amine C with dihydroxyacetone using 2-picoline·borane and reductive amination of core peptide G with side chain H using t-BuNH2·borane complex.
MissingLinkText
MissingLinkText
