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Synthesis 2014; 46(21): 2945-2950
DOI: 10.1055/s-0034-1378565
DOI: 10.1055/s-0034-1378565
paper
Stereoselective Total Synthesis of epi-Phomopsolide B
Authors
Further Information
Publication History
Received: 08 May 2014
Accepted after revision: 07 July 2014
Publication Date:
12 August 2014 (online)
Abstract
The stereoselective total synthesis of epi-phomopsolide B, a polyhydroxy lactone natural product, has been accomplished. Starting from the commercially available diethyl l-tartrate, the synthesis involved an asymmetric Evans aldol approach and Still–Gennari olefination. Further, the resulting epi-phomopsolide B was screened for cytotoxicity and antimicrobial properties, and the outcome is presented.
Key words
asymmetric Evans aldol approach - Still–Gennari olefination - diethyl l-tartrate - total synthesisSupporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/
10.1055/s-00000084. Included are 1H and 13C NMR spectra of representative compounds and procedures for the evaluation of biological
activity.
- Supporting Inf.tion (PDF)
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