Ligand-Assisted Copper-Catalyzed Oxidative Cross-Coupling of Simple Phenols with Formamides for the Synthesis of Carbamates

Abstract

An oxidative approach for the synthesis of phenyl carbamates has been achieved by ligand-assisted copper-catalyzed cross-dehydrogenative coupling (CDC) of phenols with formamides. The direct coupling of simple phenols with mono- and dialkyl form­amides provides carbamate products in moderate to good yields ­under mild reaction conditions.

Key words

oxidation - formamide - carbamate - copper acetate - coupling reaction

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