Am J Perinatol 2015; 32(03): 219-224
DOI: 10.1055/s-0034-1374816
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Impact of Neonatal Factors and Nutrition on Kidney Size in 5-Year-Old Preterm-Born Children

Sorana C. Galu
1   Neonatal Department, Maternite Regionale Universitaire, Nancy, France
,
Jean-Michel Hascoet
1   Neonatal Department, Maternite Regionale Universitaire, Nancy, France
,
Rachel Vieux
1   Neonatal Department, Maternite Regionale Universitaire, Nancy, France
2   Paediatric Nephrology Unit, CHU Nancy, Paediatric Nephrology Unit, Vandoeuvre-lès-Nancy, France
3   EA 4360 APEMAC, Université de Lorraine, Vandoeuvre-lès-Nancy, Nancy, France
› Author Affiliations
Further Information

Publication History

24 September 2013

17 March 2014

Publication Date:
24 June 2014 (online)

Abstract

Objective The aim of this article is to evaluate the influence of neonatal factors on kidney size in 5-year-old preterm-born children.

Study design Preterm-born children were examined at 5 years with kidney ultrasound.

Result A total of 20 children were evaluated. Their gestational age (GA) was 29.3 ± 1.5 weeks, birth weight 1,321 ± 323 g. On Day 28, protein intake was (median, range) 2.8 (1.7–3.6 g/kg) g/kg, protein/total calories ratio 2.8 (range, 1.7–3.3 g/100 kcal) g/100 kcal. At 5 years, their systolic blood pressure was 97 mm Hg (range, 84–115 mm Hg). All had normal estimated glomerular filtration rate. Protein intake on Day 28 and protein/calories ratio on Day 28 were associated with a low total relative renal volume, respectively, β =  − 37 ± 15, p = 0.03; β =  − 50 ± 19, p = 0.03, after adjustment on GA, neonatal morbidities, and body mass index (multivariate linear regression). Kidney size was not associated with protein intake at 5 years.

Conclusion Improving protein prescription in the neonatal period could have an impact on kidney size in childhood in preterm-born children.

Note

Authors did not receive financial support or equipments for this work.


 
  • References

  • 1 Cuzzolin L, Fanos V, Pinna B , et al. Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions. Pediatr Nephrol 2006; 21 (7) 931-938
  • 2 Luyckx VA, Brenner BM. The clinical importance of nephron mass. J Am Soc Nephrol 2010; 21 (6) 898-910
  • 3 Gubhaju L, Sutherland MR, Black MJ. Preterm birth and the kidney: implications for long-term renal health. Reprod Sci 2011; 18 (4) 322-333
  • 4 Rodríguez MM, Gómez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol 2004; 7 (1) 17-25
  • 5 Hughson M, Farris III AB, Douglas-Denton R, Hoy WE, Bertram JF. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 2003; 63 (6) 2113-2122
  • 6 Hinchliffe SA, Lynch MR, Sargent PH, Howard CV, Van Velzen D. The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol 1992; 99 (4) 296-301
  • 7 Faa G, Gerosa C, Fanni D , et al. Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. J Matern Fetal Neonatal Med 2010; 23 (Suppl. 03) 129-133
  • 8 Gubhaju L, Sutherland MR, Yoder BA, Zulli A, Bertram JF, Black MJ. Is nephrogenesis affected by preterm birth? Studies in a non-human primate model. Am J Physiol Renal Physiol 2009; 297 (6) F1668-F1677
  • 9 Sutherland MR, Gubhaju L, Moore L , et al. Accelerated maturation and abnormal morphology in the preterm neonatal kidney. J Am Soc Nephrol 2011; 22 (7) 1365-1374
  • 10 Keijzer-Veen MG, Schrevel M, Finken MJJ , et al; Dutch POPS-19 Collaborative Study Group. Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. J Am Soc Nephrol 2005; 16 (9) 2762-2768
  • 11 Brenner BM, Chertow GM. Congenital oligonephropathy: an inborn cause of adult hypertension and progressive renal injury?. Curr Opin Nephrol Hypertens 1993; 2 (5) 691-695
  • 12 Schmidt IM, Chellakooty M, Boisen KA , et al. Impaired kidney growth in low-birth-weight children: distinct effects of maturity and weight for gestational age. Kidney Int 2005; 68 (2) 731-740
  • 13 Vieux R, Hascoët JM, Franck P, Guillemin F. Increased albuminuria in 4-year-old preterm-born children with normal height. J Pediatr 2012; 160 (6) 923-928 , e1
  • 14 Yudkin PL, Aboualfa M, Eyre JA, Redman CW, Wilkinson AR. New birthweight and head circumference centiles for gestational ages 24 to 42 weeks. Early Hum Dev 1987; 15 (1) 45-52
  • 15 Haycock GB, Schwartz GJ, Wisotsky DH. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr 1978; 93 (1) 62-66
  • 16 de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007; 85 (9) 660-667
  • 17 Schwartz GJ, Haycock GB, Edelmann Jr CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58 (2) 259-263
  • 18 De Souza VC, Rabilloud M, Cochat P , et al. Schwartz formula: is one k-coefficient adequate for all children?. PLoS ONE 2012; 7 (12) e53439
  • 19 Rakow A, Johansson S, Legnevall L , et al. Renal volume and function in school-age children born preterm or small for gestational age. Pediatr Nephrol 2008; 23 (8) 1309-1315
  • 20 Keijzer-Veen MG, Devos AS, Meradji M, Dekker FW, Nauta J, van der Heijden BJ. Reduced renal length and volume 20 years after very preterm birth. Pediatr Nephrol 2010; 25 (3) 499-507
  • 21 Zaffanello M, Brugnara M, Bruno C , et al. Renal function and volume of infants born with a very low birth-weight: a preliminary cross-sectional study. Acta Paediatr 2010; 99 (8) 1192-1198
  • 22 Dinkel E, Ertel M, Dittrich M, Peters H, Berres M, Schulte-Wissermann H. Kidney size in childhood. Sonographical growth charts for kidney length and volume. Pediatr Radiol 1985; 15 (1) 38-43
  • 23 Agostoni C, Buonocore G, Carnielli VP , et al; ESPGHAN Committee on Nutrition. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50 (1) 85-91
  • 24 André JL, Deschamps JP, Guéguen R, Jacques J. Blood pressure in children and adolescents. Influence of methods of measurement — Distribution of frequent values [in French]. Arch Mal Coeur Vaiss 1981; 74 (Spec No) 3-13
  • 25 Keijzer-Veen MG, Devos AS, Meradji M, Dekker FW, Nauta J, van der Heijden BJ. Reduced renal length and volume 20 years after very preterm birth. Pediatr Nephrol 2010; 25 (3) 499-507
  • 26 Bacchetta J, Harambat J, Dubourg L , et al. Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm. Kidney Int 2009; 76 (4) 445-452
  • 27 Tsang RC, Koletzko B, Uauy R, Zlotkin SH. Nutrition need of the preterm infant. Scientific basis and practical guidelines. 2nd ed. Cincinnati, OH: Digital Educational publishing Inc; 2005
  • 28 Yeung MY. Oligonephropathy, developmental programming and nutritional management of low-gestation newborns. Acta Paediatr 2006; 95 (3) 263-267
  • 29 Cooke R, Embleton N, Rigo J, Carrie A, Haschke F, Ziegler E. High protein pre-term infant formula: effect on nutrient balance, metabolic status and growth. Pediatr Res 2006; 59 (2) 265-270
  • 30 Langley-Evans SC, Welham SJ, Jackson AA. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 1999; 64 (11) 965-974
  • 31 Painter RC, Roseboom TJ, van Montfrans GA , et al. Microalbuminuria in adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol 2005; 16 (1) 189-194
  • 32 Law CM, de Swiet M, Osmond C , et al. Initiation of hypertension in utero and its amplification throughout life. BMJ 1993; 306 (6869) 24-27
  • 33 Law CM, Shiell AW, Newsome CA , et al. Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation 2002; 105 (9) 1088-1092
  • 34 Woods LL, Rasch R. Perinatal ANG II programs adult blood pressure, glomerular number, and renal function in rats. Am J Physiol 1998; 275 (5 Pt 2) R1593-R1599
  • 35 Woods LL, Ingelfinger JR, Nyengaard JR, Rasch R. Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats. Pediatr Res 2001; 49 (4) 460-467
  • 36 Yim HE, Ha KS, Bae IS, Yoo KH, Hong YS, Lee JW. Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats. J Nutr Biochem 2012; 23 (8) 937-945
  • 37 Luyckx VA, Compston CA, Simmen T, Mueller TF. Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth. Am J Physiol Renal Physiol 2009; 297 (6) F1697-F1705
  • 38 Reverte V, Tapia A, Moreno JM , et al. Renal effects of prolonged high protein intake and COX2 inhibition on hypertensive rats with altered renal development. Am J Physiol Renal Physiol 2011; 301 (2) F327-F333
  • 39 Rios A, Vargas-Robles H, Gámez-Méndez AM, Escalante B. Cyclooxygenase-2 and kidney failure. Prostaglandins Other Lipid Mediat 2012; 98 (3-4) 86-90
  • 40 Senterre T, Rigo J. Optimizing early nutritional support based on recent recommendations in VLBW infants and postnatal growth restriction. J Pediatr Gastroenterol Nutr 2011; 53 (5) 536-542
  • 41 Singhal A, Fewtrell M, Cole TJ, Lucas A. Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. Lancet 2003; 361 (9363) 1089-1097