Die Toxine der Lebensmittelvergifter – Bakterielle Keime und ihre Wirkung

Der Verzehr verdorbener Lebensmittel birgt stets die Gefahr einer Lebensmittelvergiftung. Am häufigsten wird die Symptomatik der Vergiftung von Giftstoffen (Toxinen) ausgelöst, die von bestimmten bakteriellen Keimen gebildet werden. Hierzu gehören u.a. Toxine aus Bacillus cereus, Clostridium botulinum, Clostridium perfringens und Staphylococcus aureus. Dieser Artikel beschäftigt sich mit der Wirkungsweise der Toxine bakterieller Lebensmittelvergifter.

The consumption of spoiled food always involves the danger of food poisoning. Most frequently, poisoning symptoms are caused by toxins that are produced by certain bacteria. This includes, among other, toxins from Bacillus cereus, Clostridium botulinum, Clostridium perfringens and Staphylococcus aureus. This article deals with the mode-of-action of toxins of bacterial food poisoners.

Key words

Food poisoning - foodborne infection - bacterial toxins - toxic effects

• Literatur

• 1 Eis D. Nahrungsvermittelte Infektionen und Intoxikationen. Aus: Schauder P, Ollenschläger G, (eds). Ernährungsmedizin, 3. Auflage. München/Jena: Elsevier, Urban & Fischer; 2006
• 2 Koula-Jenik H, Kraft M, Miko M, Schulz RJ. Leitfaden Ernährungsmedizin. München: Urban & Fischer 2006;
• 3 Hof H, Dörries R. Duale Reihe Medizinische Mikrobiologie. Auflage. Stuttgart: Georg Thieme Verlag; 2009. 4.
• 4 Jenson I, Moir CJ. Foodborne Microorganisms of Public Health Significance, 5th edition. Sydney: AIFST Inc; 1997
• 5 Agata N, Mori M, Ohta M et al. A novel dodecadepsipeptide, cereulide, isolated from Bacillus cereus causes vacuole formation in HEp-2 cells. FEMS Microbiol Lett 1994; 121: 31-34
• 6 Agata N, Ohta M, Mori M, Isobe M. A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus. FEMS Microbiol Lett 1995; 129: 17-20
• 7 Mikkola R, Saris NE, Grigoriev PA et al. Ionophoretic properties and mitochondrial effects of cereulide: the emetic toxin of B. cereus. Eur J Biochem 1999; 263: 112-117
• 8 Ekman JV, Kruglov A, Andersson MA et al. Cereulide produced by Bacillus cereus increases the fitness of the producer organism in low-potassium environments. Microbiology 2012; 158: 1106-1116
• 9 Sitzmann FC, Bartmann P. Duale Reihe Pädiatrie. Auflage. 3. Stuttgart: Georg Thieme Verlag; 2006
• 10 Grehl H, Reinhardt F. Checkliste Neurologie. Auflage. Stuttgart: Georg Thieme Verlag; 2008. 4.
• 11 Johnson EA, Montecucco C. Botulism. Handb Clin Neurol 2008; 91: 333-368
• 12 Rossetto O, Megighian A, Scorzeto M, Montecucco C. Botulinum neurotoxins. Toxicon 2013; 67: 31-36
• 13 Smedley 3rd JG, Fisher DJ, Sayeed S et al. The enteric toxins of Clostridium perfringens. Rev Physiol Biochem Pharmacol 2004; 152: 183-204
• 14 Guttman JA, Finlay BB. Tight junctions as targets of infectious agents. Biochim Biophys Acta 2009; 1788: 832-841
• 15 McClane BA. The complex interactions between Clostridium perfringens enterotoxin and epithelial tight junctions. Toxicon 2001; 39: 1781-1791
• 16 McClane BA, Chakrabarti G. New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxin. Anaerobe 2004; 10: 107-114
• 17 Veshnyakova A, Protze J, Rossa J et al. On the interaction of Clostridium perfringens enterotoxin with claudins. Toxins (Basel) 2010; 2: 1336-1356
• 18 Hennekinne JA, De Buyser ML, Dragacci S. Staphylococcus aureus and its food poisoning toxins: characterization and outbreak investigation. FEMS Microbiol Rev 2012; 36: 815-836
• 19 Miron N, Miron MM. Staphylococcal enterotoxin A: a candidate for the amplification of physiological immunoregulatory responses in the gut. Microbiol Immunol 2010; 54: 769-777
• 20 Pinchuk IV, Beswick EJ, Saada JI et al. Monocyte chemoattractant protein-1 production by intestinal myofibroblasts in response to staphylococcal enterotoxin a: relevance to staphylococcal enterotoxigenic disease. J Immunol 2007; 178: 8097-8106
• 21 Ono HK, Nishizawa M, Yamamoto Y et al. Submucosal mast cells in the gastrointestinal tract are a target of staphylococcal enterotoxin type A. FEMS Immunol Med Microbiol 2012; 64: 392-402