Synthesis 2014; 46(12): 1639-1647
DOI: 10.1055/s-0033-1341154
paper
© Georg Thieme Verlag Stuttgart · New York

Iterative Iodocyclization: Total Synthesis of Polyrhacitide B

Debendra K. Mohapatra*
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: mohapatra@iict.res.in
,
P. Sivarama Krishnarao
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: mohapatra@iict.res.in
,
Eswar Bhimireddy
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: mohapatra@iict.res.in
,
Jhillu S. Yadav
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India   Fax: +91(40)27160512   Email: mohapatra@iict.res.in
› Author Affiliations
Further Information

Publication History

Received: 09 February 2014

Accepted after revision: 14 March 2014

Publication Date:
11 April 2014 (online)


Abstract

A highly stereoselective total synthesis of polyrhacitide B is reported. Key reactions are an iodocyclization protocol developed in our group, the Maruoka asymmetric allylation, the Bartlett–Smith iodocarbonate cyclization, and iodolactonization.

Supporting Information

 
  • References and Notes

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