Synthesis of 7-epi-Goniodiol by Proline-Catalyzed Diastereoselective Direct Aldol Reaction

Bacchu Veena; Gangavaram V. M. Sharma

doi:10.1055/s-0033-1341107

Synlett, Inhaltsverzeichnis

Synlett 2014; 25(09): 1283-1286
DOI: 10.1055/s-0033-1341107

letter

Synthesis of 7-epi-Goniodiol by Proline-Catalyzed Diastereoselective Direct Aldol Reaction

Bacchu Veena*

D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India Fax: +91(40)27160387 eMail: veenabachhu@gmail.com

,

Gangavaram V. M. Sharma

D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India Fax: +91(40)27160387 eMail: veenabachhu@gmail.com

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Abstract

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Abstract

A simple organocatalytic approach was developed for the total synthesis of 7-epi-goniodiol. The strategy involves l-proline-catalyzed diastereoselective direct aldol reaction and Baeyer–Villiger oxidation as key steps for the construction of chiral lactone.

Key words

styryllactones - 7-epi-goniodiol - proline - aldol reaction - Baeyer–Villiger oxidation

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Referenzen

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