Efficient Catalyst-Free One-Pot Three-Component Synthesis of Novel Spiro­oxindole Derivatives, and Their Cytotoxic Activities

Abstract

A simple and efficient one-pot approach for assembling novel spiro[indolepyranopyrrole] derivatives was developed and used to prepare a series of biologically important compounds. The reaction was easily performed with high efficiency under very simple and mild conditions without any catalysts and it gave good yields, avoiding time-consuming costly synthesis and laborious workup and purification of products. The cytotoxic activities of these new spiro[indolepyranopyrrole] derivatives were evaluated in vitro. Most of the tested compounds exhibited significant cytotoxicities to Raji cell lines.

Key words

polycyclic compounds - heterocyclic compounds - spiro compounds - multicomponent reactions - cytotoxins

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