Synthesis and Functionalization of 3-Azolylquinoxalin-2(1H)-ones

Oleksandr V. Geraschenko; Pavel V. Khodakovskiy; Oleg V. Shishkin; Andrey A. Tolmachev; Pavel K. Mykhailiuk

doi:10.1055/s-0033-1340983

Synthesis, Table of Contents

Synthesis 2014; 46(11): 1487-1492
DOI: 10.1055/s-0033-1340983

paper

Synthesis and Functionalization of 3-Azolylquinoxalin-2(1H)-ones

Oleksandr V. Geraschenko*

^aEnamine Ltd., Aleksandra Matrosova Street 23, Kyiv 01103, Ukraine

^bDepartment of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street 64, Kyiv 01033, Ukraine Fax: +380(44)2351273 Email: Geraschenko.Aleksandr@gmail.com Email: Pavel.Mykhailiuk@gmail.com

,

Pavel V. Khodakovskiy

^aEnamine Ltd., Aleksandra Matrosova Street 23, Kyiv 01103, Ukraine

^bDepartment of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street 64, Kyiv 01033, Ukraine Fax: +380(44)2351273 Email: Geraschenko.Aleksandr@gmail.com Email: Pavel.Mykhailiuk@gmail.com

,

Oleg V. Shishkin

^cSTC, Institute for Single Crystals, National Academy of Science of Ukraine, 60 Lenina Ave., Kharkiv 61001, Ukraine

,

Andrey A. Tolmachev

^aEnamine Ltd., Aleksandra Matrosova Street 23, Kyiv 01103, Ukraine

^bDepartment of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street 64, Kyiv 01033, Ukraine Fax: +380(44)2351273 Email: Geraschenko.Aleksandr@gmail.com Email: Pavel.Mykhailiuk@gmail.com

,

Pavel K. Mykhailiuk*

^aEnamine Ltd., Aleksandra Matrosova Street 23, Kyiv 01103, Ukraine

^bDepartment of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street 64, Kyiv 01033, Ukraine Fax: +380(44)2351273 Email: Geraschenko.Aleksandr@gmail.com Email: Pavel.Mykhailiuk@gmail.com

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Abstract

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Abstract

Ethyl 2-azolylglyoxylates react smoothly with o-phenylenediamines and 1,2-diaminocyclohexane in acetonitrile at room temperature to give the corresponding 3-azolylquinoxalin-2(1H)-ones and their saturated analogues in good to excellent yields.

Key words

quinoxalin-2(1H)-ones - 2-azolylglyoxylates - condensation - o-phenylenediamine - 1,2-diaminocyclohexane

Full Text

References

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