Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenyl­purines and Boronic Acids

Abstract

A palladium(II)-catalyzed, copper(I)-mediated ­Liebeskind–Srogl cross-coupling for the C-6 arylation/alkenylation on purine scaffold is reported. Various boronic acids reacted readily with 8-substituted 6-thiophenylpurines.

Key words

purine - cross-coupling - sulfur - copper - palladium

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