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Synthesis 2014; 46(09): 1236-1242
DOI: 10.1055/s-0033-1340733
DOI: 10.1055/s-0033-1340733
paper
Amidation of Aryl Halides with Isocyanides Using a Polymer-Supported Palladium–N-Heterocyclic Carbene Complex as an Efficient, Phosphine-Free and Heterogeneous Recyclable Catalyst
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Publication History
Received: 16 November 2013
Accepted after revision: 12 January 2014
Publication Date:
10 March 2014 (online)
Abstract
The amidation of aryl halides with alkyl/aryl isocyanides to give the corresponding amides using polymer-supported palladium–N-heterocyclic carbene complex (PS-Pd-NHC) as an efficient heterogeneous recyclable catalyst is described. The catalytic system was optimized with respect to various reaction parameters giving excellent yields of the desired products. The catalyst can be easily separated by a simple filtration process and recycled further for up to four consecutive recycle without any loss of activity and selectivity. The protocol is advantageous due to the ease in handling of the catalyst, simple workup procedure, phosphine-free, and effective catalyst recyclability.
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Transition-metal-free catalyzed reactions of isocyanides, see:
Transition-metal-catalyzed reactions of isocyanides, see: