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Synthesis 2014; 46(06): 822-827
DOI: 10.1055/s-0033-1340714
DOI: 10.1055/s-0033-1340714
paper
Stereoisomers of Ieodoglucomides A and B: Synthesis and Evaluation of Anticancer Activity
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Publication History
Received: 28 October 2013
Accepted after revision: 12 January 2014
Publication Date:
10 February 2014 (online)
Abstract
Asymmetric total synthesis of α-isomers of ieodoglucomides A and B along with their C14-epimers has been achieved starting from d-glucose. The key reactions involved are α-glycosylation and Grubbs olefin cross-metathesis. These stereochemical analogues and their β-isomers (natural products) were screened for their effects on cytotoxicity against various cancer cell lines and it was found that a few analogues are active relative to the natural ieodoglucomides.
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