Copper Hydride Catalyzed Reductive Aldol Addition/Lactonization Domino Reactions of α,β-Unsaturated Diesters

Abstract

The first copper-catalyzed reductive aldol addition/lactonization domino reactions of α,β-unsaturated dicarboxylate esters with ketones were achieved in high yields. The method, which involves easily available reagents, a flexible combination of reactants, and mild conditions, provides a simple route to functionalized lactones bearing an ester group.

Key words

reductions - aldol reactions - lactones - domino reactions - copper - catalysis

• References and Notes

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• 32 The stereochemistries of the 6a isomers were deduced from their NOESY spectra.