Copper Triflate: An Efficient Catalyst for Direct Conversion of Secondary Alcohols into Azides

Abstract

A simple, practical, and efficient strategy has been demonstrated for the direct synthesis of organic azides from alcohols using azidotrimethylsilane (TMSN₃) as azide source in the presence of copper(II) triflate [Cu(OTf)₂]. A variety of alcohols was converted into the corresponding azides in good to excellent yields. The formation of an intermediate carbocation was confirmed by the synthesis of bis(diphenylmethyl) ether.

Key words

azides - azidotrimethylsilane - copper triflate - Lewis acid

• References

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