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Synlett 2014; 25(4): 495-500
DOI: 10.1055/s-0033-1340478
DOI: 10.1055/s-0033-1340478
letter
A Mild and Simple Method for the Synthesis of Substituted Phenazines
Authors
Further Information
Publication History
Received: 04 September 2013
Accepted after revision: 23 November 2013
Publication Date:
20 December 2013 (online)
Abstract
A mild, simple, and general method has been developed for the synthesis of phenazines by cross-coupling of benzoquinones with o-phenylenediamines. Benzoquinones and o-phenylenediamines reacted smoothly to give the corresponding cross-coupled products in good to excellent yields. 1,4-Naphthoquinone also coupled with o-phenylenediamines in the presence of copper acetate at 50 °C to give the corresponding benzo[a]phenazines. All reactions could be carried out under air.
Key words
cross-coupling - quinones - amines - heterocycles - cyclization - polycycles - catalysis - copperSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information (PDF)
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