2,6-Difunctionalization of N-Substituted Dithienothiazines via Dilithiation

Abstract

The regioselective lithiation of dithienothiazines followed by electrophilic trapping in a one-pot fashion is an efficient route to 2-mono- and 2,6-difunctionalized dithienothiazines. A pseudo five-component dilithiation–diformylation–double-Wittig olefination sequence gives a dithienothiazine symmetrically functionalized with α,β-unsaturated ester side chains in excellent yield.

Key words

addition reactions - heterocycles - lithiation - multicomponent reactions - Wittig reactions

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