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Synthesis 2013; 45(22): 3131-3136
DOI: 10.1055/s-0033-1339848
DOI: 10.1055/s-0033-1339848
paper
Synthesis of 4-Arylquinazolines by Arylation of Quinazolin-4-ones under Mild Conditions
Authors
Weitere Informationen
Publikationsverlauf
Received: 05. Juni 2013
Accepted after revision: 25. August 2013
Publikationsdatum:
23. September 2013 (online)
Abstract
An efficient route to 4-arylquinazolines via arylation of quinazolin-4-ones under mild condition is described. The reaction is carried out by the palladium-catalyzed coupling of quinazolin-4-ones with arylboronic acids in the presence of TsCl leading to 4-arylquinazolines in good to excellent yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information (PDF)
-
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For examples, see:
For examples, see:
For examples of 4-aminoquinazolines, see:
For examples of 4-alkyl(aryl)thioquinazolines, see:
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