Improved Catalyst-Free Synthesis of Pyrrole Derivatives in Aqueous Media

Abstract

An improved catalyst-free, three-component reaction of ammonium acetate, 1,3-dicarbonyl compounds, and aromatic α-hydroxycarbonyl compounds has been carried out in water–ethanol (50:50) under reflux conditions. The improvement of yield in this aqueous medium is attributed to a combination of increased association of the reactants by hydrophobic interactions and precipitation of the product during the reaction. This operationally simple procedure is less laborious and provides a better scope and chemoselectivity than previously reported procedures.

Key words

catalyst-free - multicomponent reaction - aqueous medium - pyrrole derivatives - α-hydroxycarbonyl compounds

• References and Notes

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