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Synlett 2014; 25(13): 1873-1878
DOI: 10.1055/s-0033-1338646
DOI: 10.1055/s-0033-1338646
letter
Metal-Free: A Novel and Efficient Aerobic Oxidation of Primary Amines to Oximes Using N,N′,N″-Trihydroxyisocyanuric Acid and Acetaldoxime as Catalysts in Water
Further Information
Publication History
Received: 18 March 2014
Accepted after revision: 25 April 2014
Publication Date:
09 July 2014 (online)
Abstract
A general, efficient, and metal-free method for aerobic oxidation of aromatic primary amines to the corresponding oximes catalyzed by N,N′,N″-trihydroxyisocyanuric acid and acetaldoxime with water as solvent is described. This practical method can use air as economic and green oxidant, water as green solvent, and tolerates a wide range of substrates, which can afford the target oximes in moderate to good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
-
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