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Synthesis 2014; 46(08): 1085-1090
DOI: 10.1055/s-0033-1338598
DOI: 10.1055/s-0033-1338598
paper
Cheap and Easy Synthesis of Highly Functionalized (Het)aryl Iodides via the Aromatic Finkelstein Reaction
Authors
Further Information
Publication History
Received: 20 January 2014
Accepted after revision: 28 January 2014
Publication Date:
26 February 2014 (online)
Abstract
Aryl iodides are superior coupling partners in cross-coupling reactions compared to the corresponding chlorides or bromides. Unfortunately, the iodides are much more expensive, if commercially available at all, than the other halides. Thus, it is often mandatory to transform the available bromides into the corresponding iodides. The copper-catalyzed aromatic Finkelstein reaction turned out to be the method of choice to prepare a number of highly functionalized iodo(het)aryls, including pyridines, 2,2′-bipyridines, and chiral compounds.
Key words
halogen exchange - aromatic Finkelstein reaction - copper catalysis - aryl bromides - aryl iodidesSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information (PDF)
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