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Synthesis 2013; 45(11): 1452-1461
DOI: 10.1055/s-0033-1338470
DOI: 10.1055/s-0033-1338470
feature article
Synthesis of Functionalized Adamantane Derivatives: (3 + 1)-Scaffolds for Applications in Medicinal and Material Chemistry
Further Information
Publication History
Received: 16 March 2013
Accepted after revision: 05 April 2013
Publication Date:
24 April 2013 (online)
Abstract
Due to its rigid cage structure, adamantane has received considerable interest as a scaffold with a defined tetrahedral geometry. In this paper we describe orthogonally functionalized tetrasubstituted adamantane derivatives. These compounds may be conjugated to other functional molecules by standard techniques such as amide formation or click chemistry and are thus useful (3 + 1) scaffolds for medicinal and material chemistry.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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