Synthesis 2013; 45(12): 1701-1707
DOI: 10.1055/s-0033-1338451
paper
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Oxidation of Deoxybenzoins to Benzils under Aerobic Conditions

Sandro Cacchi
Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Fax: +39(06)49912780   Email: antonella.goggiamani@uniroma1.it
,
Giancarlo Fabrizi
Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Fax: +39(06)49912780   Email: antonella.goggiamani@uniroma1.it
,
Antonella Goggiamani*
Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Fax: +39(06)49912780   Email: antonella.goggiamani@uniroma1.it
,
Antonia Iazzetti
Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Fax: +39(06)49912780   Email: antonella.goggiamani@uniroma1.it
,
Rosanna Verdiglione
Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Fax: +39(06)49912780   Email: antonella.goggiamani@uniroma1.it
› Author Affiliations
Further Information

Publication History

Received: 17 January 2013

Accepted after revision: 08 April 2013

Publication Date:
15 May 2013 (online)


Abstract

A novel copper-catalyzed approach to benzils from readily available deoxybenzoins under neutral conditions using air as the oxidant has been developed. The reaction tolerates a variety of useful substituents including chloro, bromo, iodo, keto, ester, and cyano groups.

Supporting Information

 
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