Mechanistic Insight to the Reaction Pathway of Aerobic Oxidative C–C Bond Cleavage of α-Hydroxy Ketones

Abstract

A novel transition-metal-free aerobic oxidative C–C bond-cleavage method has been developed. Oxygen, the ideal oxidant, was used as the oxidizing reagent. The dimeric intermediate and ¹⁸O-isotopic-labeling control experiments partially disclosed the reaction mechanism.

Key words

α-hydroxy ketones - esterification - aerobic oxidation - C–C bond cleavage - transition-metal-free

• References


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