Thorac Cardiovasc Surg 2014; 62(02): 109-116
DOI: 10.1055/s-0032-1329191
Original Thoracic
Georg Thieme Verlag KG Stuttgart · New York

T1aN0M0 and T1bN0M0 Non–Small Cell Lung Cancer: A Retrospective Study of the Prognosis

Zhenfa Zhang
1   Department of Lung Cancer, Lung Cancer Center, Tian Jin Medical University Cancer Institute and Hospital, Tian Jin, People's Republic of China
,
Anlei Wang
1   Department of Lung Cancer, Lung Cancer Center, Tian Jin Medical University Cancer Institute and Hospital, Tian Jin, People's Republic of China
,
Zhongli Zhan
2   Department of Pathology, Tian Jin Medical University Cancer Institute and Hospital, Tian Jin, People's Republic of China
,
Leina Sun
2   Department of Pathology, Tian Jin Medical University Cancer Institute and Hospital, Tian Jin, People's Republic of China
,
Kexin Chen
3   Department of Epidemiology, Tian Jin Medical University Cancer Institute and Hospital, Tian Jin, People's Republic of China
,
Changli Wang
1   Department of Lung Cancer, Lung Cancer Center, Tian Jin Medical University Cancer Institute and Hospital, Tian Jin, People's Republic of China
› Author Affiliations
Further Information

Publication History

04 April 2012

20 June 2012

Publication Date:
06 December 2012 (online)

Abstract

Background Stage IA of non–small cell lung cancer (NSCLC) is divided into two subgroups, T1aN0M0 (d ≤ 2 cm) and T1bN0M0 (2 < d ≤ 3 cm), in the International Association for the Study of Lung Cancer, seventh edition of TNM Classification of Malignant Tumors.

Objective The purpose of this study was the identification of independent clinicopathological predictors of prognosis of these two subgroups of NSCLC.

Methods Between 1986 and 2005, a cohort of 1,929 cases of stage IA NSCLC in Tian Jin Medical University Cancer Institute and Hospital were retrospectively analyzed. The impact of clinicopathological characteristics on patients' survival was investigated.

Results The overall 5-year survival rate was 71.07%. Patients with T1aN0M0 NSCLC had a better 5-year survival than those with T1bN0M0 (73.98 vs. 68.18%, p = 0.0135). The Cox proportional hazard model revealed that the prognostic factors of T1aN0M0 were intratumoral vessel invasion (p = 0.035) and histologic differentiation (p = 0.004). In patients with T1bN0M0 NSCLC, the prognostic factors were histologic differentiation (p < 0.01), intratumoral vessel invasion (p < 0.01), removal of 6 or more lymph node stations (p < 0.01), and removal of lymph node station 7 (p < 0.01).

Conclusion Prognostic factors of T1aN0M0 and T1bN0M0 NSCLC are different. In patients with T1bN0M0 NSCLC, 6 or more lymph node stations and lymph node station 7 should be removed.

 
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