Anti-inflammatorische Wirkungen der Tee-Flavonoide

Zusammenfassung

Tee-Flavonoide gehören zu den Polyphenolen und haben antioxidative, antiinflammatorische und antineoplastische Eigenschaften. Diese Phytochemikalien sind körperfremde Substanzen und werden durch Teepflanzen synthetisiert (Botanicals). Sie haben zum Teil ähnliche Wirkungen wie die sogenannten Biologicals und hemmen immunologisch aktive Zellen und Cytokine. Kranke mit chronisch-entzündlich aktivierten Signalwegen könnten durch eine Behandlung mit Flavonoiden profitieren. Eine gesteigerte, diätetische Flavonoidzufuhr könnte als neue Therapie-Form bei Patienten mit chronisch entzündlichen Darmkrankheiten, Reizdarm sowie zur Prävention von intestinalen Neoplasien eingesetzt werden. Um diese neue Therapie-Form zu evaluieren sind Interventions-Studien im Sinne von kontrollierten randomisierten Klinischen Studien notwendig.

Abstract

Tea flavonoids belong to the large group of polyphenols and display antioxidative, anti-inflammatory and anti-neoplastic activities. These phytochemicals are xenobiotics and are synthesized by tea plants such as Camellia sinensis and Camomilla recucita. These botanicals exhibit in vivo activities similar to that of biologicals which are widely used for chronic inflammatory diseases (rheumatoid arthritis, chronic inflammatory bowel disease). Epigallocathechin gallate and apigenin from these plants inhibit cytokines, chemokines and activated immune cells in vivo and in vitro. Clinical disorders with induced inflammatory pathways could benefit from flavonoid treatment. Dietary supplementation with specific tea-flavonoids could be used for Crohn’s disease, ulcerative colitis and irritable bowel syndrome. Suppression of cytokine production could ultimately lead to inhibition of carcinogenesis. This mechanism could explain why flavonoids are effective in the prevention of intestinal neoplasia. This innovative new form of therapy should be tested in controlled, randomized clinical studies.

Schlüsselwörter

Flavonoide - Grüntee - Kamille - chronische Entzündungsreaktion - Cytokine - Chemokine - chronisch-entzündliche Darmkrankheiten

Keywords

flavonoids - anti-inflammation - green tea - chronic inflammatory reaction - cytokine - chemokines - inflammatory bowel disease

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