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Synthesis 2013; 45(8): 1099-1105
DOI: 10.1055/s-0032-1318486
DOI: 10.1055/s-0032-1318486
paper
A Practical Protocol for the Conjugation of Various Amino Acids to Protoporphyrin IX
Further Information
Publication History
Received: 08 January 2013
Accepted after revision: 25 February 2013
Publication Date:
21 March 2013 (online)
Abstract
An effective and reliable method was developed for the synthesis of protoporphyrin IX-derived amides. The reaction of protoporphyrin IX with an amino acid [l-leucine, l-valine, l-lysine, l-aspartic acid (Asp), l-glutamic acid (Glu), glycine, or 6-aminohexanoic acid] or a short peptide (Asp-Glu) as an amine counterpart in the presence of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate and 1H-1,2,3-benzotriazol-1-ol gave the desired diamides in excellent yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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