A Formal Synthesis of (±)-Cephalotaxine via Pauson–Khand Reaction

Abstract

A concise route toward the formal synthesis of (±)-cephalotaxine has been developed. An intermolecular Pauson–Khand reaction was adopted to construct the cyclopentenone ring efficiently with high regioselectivity.

Key words

(±)-cephalotaxine - alkaloids - intermolecular Pauson–Khand reaction - cycloaddition - cyclopentenones - regioselectivity

• References


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