Synthesis 2013; 45(2): 219-224
DOI: 10.1055/s-0032-1317930
paper
© Georg Thieme Verlag Stuttgart · New York

A Rapid and Convenient Microwave-Promoted Synthesis of 3,5-Disubstituted 2-Chloropyridines and Their Conversion into Tetrazolo[1,5-a]pyridines

Shyamalee Gogoi
Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India   Fax: +91(376)2370011   Email: rc_boruah@yahoo.co.in
,
Sanjib Gogoi
Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India   Fax: +91(376)2370011   Email: rc_boruah@yahoo.co.in
,
Romesh C. Boruah*
Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India   Fax: +91(376)2370011   Email: rc_boruah@yahoo.co.in
› Author Affiliations
Further Information

Publication History

Received: 12 November 2012

Accepted: 27 November 2012

Publication Date:
12 December 2012 (online)


Abstract

This work describes a rapid and convenient synthesis of 3,5-disubstituted 2-chloropyridines from various α,β-unsaturated ketoximes utilizing the Vilsmeier reaction under microwave irradiation. The 3,5-disubstituted 2-chloropyridines were further converted into tetrazolo[1,5-a]pyridines by a microwave-mediated solid-phase reaction. The products were isolated in good yields within a very short reaction time.

Supporting Information

 
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