Samarium Diiodide Mediated Highly Diastereoselective Conjugate Reduction of the α,β-Unsaturated Ester Moiety in Heterocyclic Compounds

Abstract

Tetrahydropyrazolopyrazolones and a tetrahydropyrazolodiazocinone containing an α,β-unsaturated ester moiety undergo highly diastereoselective conjugate reduction mediated by samarium diiodide in the mixed solvent tetrahydrofuran and ethanol to give the corresponding products as single diastereomers in moderate to good yields.

Key words

samarium diiodide - reduction - α,β-unsaturated ester - conjugate - heterocycle

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