An effective and practical method has been developed for the diversity-oriented synthesis of trans-4,6-diaryl-5-nitropiperidin-2-ones via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, dimethyl malonate, and formamide for the generation of a wide range of structurally interesting and pharmacologically significant compounds. It is worth mentioning that in the course of this reaction, the formation of products was highly stereoselective.
Key words
multicomponent reaction - combinatorial chemistry - piperidines - Michael addition - piperidin-2-ones