Template Synthesis of endo-Functionalized Macrocycles Using Boronic Esters of Tetraols Followed by Ring-Closing Metathesis^[1]

Abstract

Several stiff tetraols can be used as templates for the synthesis of bimacrocyclic diboronic esters. The endo-boronic acid functionalities can be substituted to give new endo-functionalized macrocycles (phenols, biphenyls) or new bimacrocycles (concave pyridines or concave 1,10-phenanthrolines).

Key words

macrocycles - supramolecular chemistry - receptors - boronic acids - molecular recognition

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